SECRETION OF EXTRACELLULAR PROTEINS BY ENTEROHEMORRHAGIC ESCHERICHIA-COLI VIA A PUTATIVE TYPE-III SECRETION SYSTEM

Authors
JARVIS KG KAPER JB
Citation
Kg. Jarvis et Jb. Kaper, SECRETION OF EXTRACELLULAR PROTEINS BY ENTEROHEMORRHAGIC ESCHERICHIA-COLI VIA A PUTATIVE TYPE-III SECRETION SYSTEM, Infection and immunity, 64(11), 1996, pp. 4826-4829
Citations number
30
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
11
Year of publication
1996
Pages
4826 - 4829
Database
ISI
SICI code
0019-9567(1996)64:11<4826:SOEPBE>2.0.ZU;2-U
Abstract
Enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC ) infections result in attaching and effacing lesions on intestinal ep ithelial cells. Secretion of extracellular proteins via a type III sec retion apparatus is necessary for the formation of attaching and effac ing lesions by EPEC. We now show that EHEC also secretes polypeptides via a putative type III secretion system. The secreted EHEC proteins a re recognized by rabbit antiserum raised against the proteins secreted from EPEC and by human serum from a patient infected with an EHEC O15 7:H7 strain.