THE HTRA STRESS-RESPONSE PROTEASE CONTRIBUTES TO RESISTANCE OF BRUCELLA-ABORTUS TO KILLING BY MURINE PHAGOCYTES

Authors
ELZER PH PHILLIPS RW ROBERTSON GT ROOP RM
Citation
Ph. Elzer et al., THE HTRA STRESS-RESPONSE PROTEASE CONTRIBUTES TO RESISTANCE OF BRUCELLA-ABORTUS TO KILLING BY MURINE PHAGOCYTES, Infection and immunity, 64(11), 1996, pp. 4838-4841
Citations number
30
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
11
Year of publication
1996
Pages
4838 - 4841
Database
ISI
SICI code
0019-9567(1996)64:11<4838:THSPCT>2.0.ZU;2-M
Abstract
Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 shows decreased resistance to killing bg cultured murine neutrop hils and macrophages and significant attenuation during the early stag es of infection in the BALB/c mouse model. These findings further defi ne the contributions of the htrA gene product to the pathogenesis of B . abortus infections.