A prototype bench top model of a continuous flow ventricular assist de
vice using an impeller suspended by magnetic bearings has been develop
ed. Generation of a pulsatile pressure was studied using both a comput
er model and in vitro loop tests of the prototype. The motivation for
developing a computer model for a blood pump in the natural circulatio
n is two-fold. First, it allows simulation of the pump under a large v
ariety of operating conditions. Second, it provides insight into what
parameters of the system design are important for achieving a specific
result. For example, in one case, an aortic pressure of 118/87 mmHg w
as generated by varying the speed from 2,000 to 2,600 rpm. The compute
r model was verified by coupling the centrifugal pump prototype to a m
ock circulatory system. The results of the model were verified by gene
rating an aortic pressure of 113/78 mmHg while varying the speed from
2,000 to 2,600 rpm. These experiments have shown that it is possible t
o generate pulsatile pressure similar to that of native physiology usi
ng a centrifugal left ventricular assist device. further tests will be
required to quantify the effects on hemolysis.