THERAPEUTIC MONITORING OF 120 HOURS CONTI NUOUS 5-FLUOROURACIL ASSOCIATED WITH CISPLATIN

For 31 patients treated by continuous 5-fluorouracil with cisplatin, a therapeutic monitoring of 5-fluorouracil is performed, based on the 4 8 first hours area under the curve (AUC) and the total AUC. The 5-fluo rouracile taylorization allows to reduce some toxicity's while preserv ing art efficiency (objective responses 42%). Many patients are consid ered with potentially low 5-fluorouracile clearance. Dose reductions o f 5-fluorouracile are frequent, reach 50% during the third cure and al low the achievement of targeted AUC. The role of cisplatin in this nec essary reduction of dose is unknown.