INTRAPERITONEAL HYPERTHERMIC PERFUSION (IPHP) - ANALYSIS OF MORBIDITYAND TOXICITY

Intraperitoneal hyperthermic perfusion (IPHP) with a solution that con tains CDDP (25 mg/m(2)/l) and MMC (3.3 mg/m(2)/l) was clinically intro duced in the treatment of peritoneal carcinomatosis. Twenty-six patien ts underwent surgical treatment and IPHP. Peritoneal carcinomatosis wa s classified at laparotomy using the Japanese classification: P1 (n=3) , P2 (n=5), P3 (n=15), unclassifiable (n=3). In this series of patient s only the creatinine and amylase values were significant in biologica l toxicity evaluation. The surgical complication rate (2 duodenal fist ulas) does not differ from the general extensive abdominal surgery.