BRADYKININ STIMULATION DOES NOT INDUCE INTRACELLULAR CA2+ ELEVATION IN CELLS FROM DESMOID TUMORS

Authors
CASSANO G SUSCA F LIPPE C GUANTI G
Citation
G. Cassano et al., BRADYKININ STIMULATION DOES NOT INDUCE INTRACELLULAR CA2+ ELEVATION IN CELLS FROM DESMOID TUMORS, Oncology Reports, 3(6), 1996, pp. 1161-1163
Citations number
10
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
3
Issue
6
Year of publication
1996
Pages
1161 - 1163
Database
ISI
SICI code
1021-335X(1996)3:6<1161:BSDNII>2.0.ZU;2-B
Abstract
The intracellular mechanisms controlling cell proliferation in desmoid tumors (DT) are unknown. Bradykinin stimulated an increase in [Ca2+]( i), (monitored by the fura-2 fluorescence) in fibroblasts obtained fro m both the skin of a normal donor and the mesenter of a familial adeno matous polyposis (FAP) patient. Cells from DT of the same patient as w ell as those from another FAP patient failed to show the elevation of [Ca2+](i) usually caused by bradykinin stimulation.