TROPISETRON-DEXAMETHASONE COMBINATION FOR CARBOPLATIN-INDUCED EMESIS

Sixty-six patients being given polychemotherapy schedules including ca rboplatin entered an antiemetic protocol with tropisetron and dexameth asone at the dose of 5 mg and 8 mg respectively. A complete response ( no episodes of vomiting) and a major response (less than or equal to 2 episodes of vomiting) were observed in 55 and and 7 patients respecti vely. It is concluded that the tropisetron-dexamethasone combination i s highly active in the control of emesis induced by conventional doses of carboplatin in combination.