APPLICATION OF ERIOCHROME CYANINE-R TO THE EXTRACTIVE-SPECTROPHOTOMETRIC DETERMINATION OF CHLORPROMAZINE

Chlorpromazine reacts with Eriochrome Cyanine R forming an ion associa tion compound, insoluble in water but fairly soluble in buthyl alcohol . In this work the optimal reaction and extraction conditions were est ablished. The spectroscopic studies of the formed compound were perfor med by UV, VIS, IR, H-1 NMR and C-13 NMR spectrometry. The new extract ive-spectrophotametric method for chlorpromazine hydrochloride determi nation is proposed. Using this method it is possible to determine chlo rpromazine hydrochloride concentration in the range 7.0-70 mu g/ml. Th is method was verified against the method of Blazek and applied to det ermination of chlorpromazine hydrochloride in pharmaceuticals.