2 CONSECUTIVE COURSES OF RH-G-CSF-MOBILIZED PERIPHERAL-BLOOD STEM-CELLS FOR PRIMARY MARROW ALLOENGRAFTMENT FAILURE - CASE-REPORT

We describe herein a case of bone marrow failure in a 53-year-old pati ent affected by Ph1-positive chronic myeloid leukemia who received an HLA-identical ABO-mismatched bone marrow transplant from a 56-year-old sibling donor. Hematopoietic recovery after marrow failure was obtain ed following two consecutive courses of rh-G-CSF-mobilized peripheral blood stem cell infusions. No potential risk factors associated with g raft failure, excluding recipient and donor age, were documented, wher eas a relatively high number of progenitor cells were necessary to ove rcome the host-versus-graft barrier in our patient. Therefore we sugge st that growth factor-stimulated peripheral blood should be considered as the first choice for allogeneic stem cells in order to avoid prima ry graft failure with donors over 50 years of age.