We present a 38-year-old woman who had experienced an acute febrile il
lness lasting more than 1 week at the age of 6, with erythema on the p
alms and soles following skin desquamation in the subacute phase and s
kin eruption. Thirty one years later, she experienced acute myocardial
infarction and episodes of angina pectoris. She had no coronary risk
factors or autoimmune diseases. Coronary angiography revealed an aneur
ysm df the proximal left coronary artery with occluded lesions at the
distal site. The right coronary artery was also occluded at the proxim
al site. These findings strongly suggest Kawasaki disease should be co
nsidered in the differential diagnosis of early-onset ischemic heart d
isease in young adults.