ALTERED NUCLEAR MATRIX PROTEIN PROFILES IN ONCOGENE-TRANSFORMED MOUSEFIBROBLASTS EXHIBITING HIGH METASTATIC POTENTIAL

The nuclear matrix provides the structural support of the nucleus and is involved in various cellular functions of the nucleus. Nuclear matr ix proteins, which are both tissue and cell type specific, are altered with transformation and state of differentiation. Here, nuclear matri x protein profiles of oncogene-transformed mouse fibroblasts with vari ous degrees of metastatic activity were analyzed using two-dimensional gel electrophoresis. This study shows that as the metastatic potentia l increases, similar nuclear matrix protein profiles are associated wi th each increase regardless of transformation agent.