Scale-up and commercialization of any chemical process is an inexact s
cience and the scale-up of fluidized bed processes is especially so. T
he problem of gas bypassing and poor contact with bed particles has be
en recognized as a major scaling consideration for a generation. More
recently, especially in circulating fluidized beds, the issues of part
icle flow patterns and density profiles have become appreciated as imp
ortant unknowns in scale-up. Equally important scale-up difficulties o
ccur outside the realm of reaction engineering, having to do with the
physical nature of solid particles. The importance of all these factor
s will be discussed with reference to the commercialization of several
fluid bed processes.