HEMATOPOIETIC AND REPRODUCTIVE HAZARDS OF KOREAN ELECTRONIC WORKERS EXPOSED TO SOLVENTS CONTAINING 2-BROMOPROPANE

Objectives The purpose of this study was to describe hematopoietic and reproductive hazards of Korean electronic workers exposed to solvents containing 2-bromopropane. Methods Detailed medical and occupational histories were taken and thorough physical examinations with clinical laboratory tests were done for 33 workers (8 men and 25 women). Previo us and present exposure was investigated in detail by industrial hygie nists. Results Of the 25 female workers, 16 were shown to have seconda ry amenorrhea with high follicle-stimulating hormone levels, normal pr olactin levels, and hot flashes. A total of eight workers with amenorr hea concurrently showed findings of pancytopenia. Among eight male wor kers, two showed azoospermia and another four showed some degree of ol igospermia (normal >20 million . ml(-1)) or reduced sperm motility (no rmal >50%). The bone marrow effects and the testis or ovarian failure was shown to be the main health hazards in this workplace. Except for the cleaning solution containing 97.4% 2-bromopropane, no other known physical or chemical agents could be identified as responsible for the gonadal and bone marrow effects, including ionizing radiation, lead, ethylene glycol ether and its acetates, benzene, and dibromochloroprop ane. Conclusions No previous studies have reported human toxicity for 2-bromopropane, but the results of this study lead to the tentative co nclusion that the causal agent for the gonadal and bone marrow effects among the workers might be 2-bromopropane.