PROGNOSTIC-SIGNIFICANCE OF PATHOLOGICAL CHEST RADIOGRAPHY IN TRANSPLANT PATIENTS AFFECTED BY CYTOMEGALOVIRUS AND OR PNEUMOCYSTIS-CARINII/

Purpose: In order to evaluate the prognostic significance of chest fil m findings in connection with cytomegalovirus (CMV) and/or pneumocysti s carinii infection (PC), a retrospective review was made of the pulmo nary charts of 274 recipients of kidney and/or pancreatic grafts trans planted between April 1987 and December 1990. Material, Methods and Re sults: Positive laboratory findings for CMV and/or PC were seen in 92 patients. In 77 patients only CMV was found, 13 patients had both CMV and PC, and 2 patients had only PC. In 57 patients a chest examination was performed. The films were reviewed by 2 radiologists independentl y. In 32 patients normal chest film findings were seen, while 25 patie nts demonstrated pathological changes. Of the patients with pathologic al changes 3 had only pleuritis while the remaining 22 demonstrated pa renchymal infiltrations. No deaths occurred among patients infected wi th CMV and/or PC, when the chest film findings were normal or pleuriti s only was seen, but there were 9 deaths in the group of patients with parenchymal infiltrations. Of the patients who died, 2 had only CMV, 5 had both CMV and PC, and 2 had only PC. The overall mortality, regar dless of radiological findings, did not exceed 3% in patients with CMV only, but increased to 38% in patients with both CMV and PC. In patie nts with parenchymal infiltrations the corresponding mortality figures were increased to 18% and 56%, respectively. Conclusion: We conclude that a radiologically verified pneumonia related to the infectious age nt influences the prognosis, and that CMV pneumonia has a better progn osis than PC pneumonia.