IDENTIFICATION OF THE SUGARS INVOLVED IN MYCOBACTERIAL CELL-AGGREGATION

Incubation of Mycobacterium tuberculosis and M. smegmatis cells with t he sugar components of their surface-exposed glycans demonstrated that D-arabinose, but not alpha-D-glucose or D-mannose, led to the dispers ion of the large clumps formed by the bacilli in stationary liquid cul tures. These results confirm the presence of arabinose-containing glyc ans on the mycobacterial cell surface and demonstrate the implication of selective sugars in cell aggregation, suggesting that the clumping of mycobacterial cells is probably mediated by lectin-carbohydrate int eractions.