ISOLATION OF 2 CYTOTOXIC DITERPENES FROM THE FERN PTERIS-MULTIFIDA

Authors
WOERDENBAG HJ LUTKE LR BOS R STEVENS JF HULST R KRUIZINGA WH ZHU YP ELEMA ET HENDRIKS H VANUDEN W PRAS N
Citation
Hj. Woerdenbag et al., ISOLATION OF 2 CYTOTOXIC DITERPENES FROM THE FERN PTERIS-MULTIFIDA, Zeitschrift fur Naturforschung. C, A journal of biosciences, 51(9-10), 1996, pp. 635-638
Citations number
11
Categorie Soggetti
Biology
Journal title
Zeitschrift fur Naturforschung. C, A journal of biosciences → ACNP
ISSN journal
09395075
Volume
51
Issue
9-10
Year of publication
1996
Pages
635 - 638
Database
ISI
SICI code
0939-5075(1996)51:9-10<635:IO2CDF>2.0.ZU;2-J
Abstract
From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) t wo diterpenes, ent-kaurane-2 beta,16 alpha-diol and ent-kaur-16-ene-2 beta,15 alpha-diol, were isolated by repeated column chromatography us ing silica gel and silica gel impregnated with silver nitrate. The str uctures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.