STUDIES TOWARDS THE SYNTHESIS OF RADIOLABELED R106-1(LY295337)

Authors
RODRIGUEZ MJ ZWEIFEL MJ
Citation
Mj. Rodriguez et Mj. Zweifel, STUDIES TOWARDS THE SYNTHESIS OF RADIOLABELED R106-1(LY295337), Journal of labelled compounds & radiopharmaceuticals, 38(11), 1996, pp. 979-987
Citations number
15
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
38
Issue
11
Year of publication
1996
Pages
979 - 987
Database
ISI
SICI code
0362-4803(1996)38:11<979:STTSOR>2.0.ZU;2-1
Abstract
A unique semisynthetic pathway has been used as a route to acquire rad iolabeled material of a complex natural product, R106. The retro-aldol reaction of R106-1 gave a key intermediate R106-sarcosine that was us ed in a subsequent aldol reaction to incorporate acetone-[2-C-14].