SYNTHESIS OF DEUTERATED CLENBUTEROL

Authors
JORGENSEN O EGSGAARD H LARSEN E
Citation
O. Jorgensen et al., SYNTHESIS OF DEUTERATED CLENBUTEROL, Journal of labelled compounds & radiopharmaceuticals, 38(11), 1996, pp. 1007-1014
Citations number
11
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
38
Issue
11
Year of publication
1996
Pages
1007 - 1014
Database
ISI
SICI code
0362-4803(1996)38:11<1007:SODC>2.0.ZU;2-6
Abstract
The synthesis of D-9-clenbuterol (I) and D-3-clenbuterol (II) is descr ibed. D-9-clenbuterol (I) was prepared from 4-amino-alpha-bromo-3,5-di chloroacetophenone by reaction with D-9-tert-butylamine followed by re duction of the keto group with NaBH4. D-3-clenbuterol (II) was prepare d from ino-alpha-tert-butylamino-3,5-dichloroacetophenone by an exchan ge reaction of the alpha-hydrogens with deuterium followed by reductio n of the keto group with NaBD4. The eventual products were characteriz ed by mass spectrometry and NMR.