Citation
D. Hesk et al., SYNTHESIS OF H-3 AND C-14-LABELED SCH-48461, Journal of labelled compounds & radiopharmaceuticals, 38(11), 1996, pp. 1039-1046
Citations number
7
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
ISSN journal
03624803
Volume
38
Issue
11
Year of publication
1996
Pages
1039 - 1046
Database
ISI
SICI code
0362-4803(1996)38:11<1039:SOHACS>2.0.ZU;2-C
Abstract
H-3-Sch 47949, racemic H-3-Sch 48461, was prepared at a specific activ
ity of 40 mCi/mmole by Pt catalysed exchange with tritiated water. H-3
-Sch 48461 was prepared at a specific activity of 64.6 Ci/mmole by a P
d/C catalysed reduction of an olefinic intermediate. C-14-Sch 48461 wa
s prepared in 8 steps from C-14-potassium cyanide with an overall radi
ochemical yield of 18.5%.