REACTIVE DISULFIDE BONDS IN IMMUNOGLOBULIN-G - A UNIQUE FEATURE IN SERUM-PROTEINS OF DIFFERENT SPECIES

Authors
SCHAUENSTEIN E SCHAUENSTEIN K DACHS F REITER M LEITSBERGER A WEBLACHER M MANINGER K HOREJSI H STEINSCHIFTER W HIRSCHMANN C FELSNER P
Citation
E. Schauenstein et al., REACTIVE DISULFIDE BONDS IN IMMUNOGLOBULIN-G - A UNIQUE FEATURE IN SERUM-PROTEINS OF DIFFERENT SPECIES, Biochemistry and molecular biology international, 40(3), 1996, pp. 433-446
Citations number
25
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
40
Issue
3
Year of publication
1996
Pages
433 - 446
Database
ISI
SICI code
1039-9712(1996)40:3<433:RDBII->2.0.ZU;2-M
Abstract
A reactive disulfide bond (SS) was detected and characterized in IgG of humans, rats and mice by virtue of disulfide interchange with dithi onitrobenzoate. (SS) was found exclusively in human IgG1 and rat IgG2 b. In human IgG1 (SS) was identified as the upper one of the two inte rheavy bridges in the hinge, where it appears to take part in compleme nt activation. The biological significance of(SS) in IgG was underlin ed by the fact that no other serum proteins were found to exhibit a si milar reactivity.