CARBON-DISULFIDE INDUCED POLYNEUROPATHY - SURAL NERVE PATHOLOGY, ELECTROPHYSIOLOGY, AND CLINICAL CORRELATION

We report the clinical features, electrophysiological studies, sural n erve pathology and recovery course of carbon disulfide-(CS2) induced p olyneuropathy in a 48-year-old man who worked in a viscose rayon plant . Sural nerve biopsy 2 years later still showed degeneration of both a xon and myelin with a predominant loss of large myelinated fibers and remyelination. Electrophysiologic studies revealed mixed axonal and de myelinating polyneuropathy. To our knowledge, this is the first human report of sural nerve pathology in the recovery stage due to CS2 intox ication. After diagnosis, the patient was removed rom the toxic enviro nment. in the following three years, he sowed part recovery predominan tly in motor function compatible with the serial nerve conduction stud ies We conclude that CS2 polyneuropathy may partly recover years after cessation of exposure.