INTERLEUKIN-4 STIMULATES RHEUMATOID SYNOVIAL FIBROBLASTS TO EXPRESS MATRIX METALLOPROTEINASE-1 (TISSUE COLLAGENASE) AND HISTAMINE H1 RECEPTOR MESSENGER-RNA

Authors
ZENMYO M HIRAOKA K SASAGURI T KOMIYA S INOUE A MORIMATSU M SASAGURI Y
Citation
M. Zenmyo et al., INTERLEUKIN-4 STIMULATES RHEUMATOID SYNOVIAL FIBROBLASTS TO EXPRESS MATRIX METALLOPROTEINASE-1 (TISSUE COLLAGENASE) AND HISTAMINE H1 RECEPTOR MESSENGER-RNA, Biochemistry and molecular biology international, 40(6), 1996, pp. 1253-1260
Citations number
35
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
40
Issue
6
Year of publication
1996
Pages
1253 - 1260
Database
ISI
SICI code
1039-9712(1996)40:6<1253:ISRSFT>2.0.ZU;2-7
Abstract
In the present study, we investigated the effect of interleukin-4 (IL- 4) on metalloproteinase 1 (MMP-1/tissue collagenase) production in hum an rheumatoid synovial fibroblasts. Northern blot analysis revealed th at addition of IL-4 with or without histamine stimulated the cells to increase the amount of proMMP-1 mRNA, and the IL-4 with histamine addi tion resulted in a 3.3-fold increase compared with histamine only. Fur thermore, IL-4 itself stimulated the expression of histamine H1 recept or mRNA. These results suggest that IL-4 may play an important role in joint destruction in RA.