MEASURING AND TESTING GENETIC DIFFERENTIATION WITH ORDERED VERSUS UNORDERED ALLELES

Authors
Citation
O. Pons et Rj. Petit, MEASURING AND TESTING GENETIC DIFFERENTIATION WITH ORDERED VERSUS UNORDERED ALLELES, Genetics, 144(3), 1996, pp. 1237-1245
Citations number
13
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
00166731
Volume
144
Issue
3
Year of publication
1996
Pages
1237 - 1245
Database
ISI
SICI code
0016-6731(1996)144:3<1237:MATGDW>2.0.ZU;2-Z
Abstract
Estimates and variances of diversity and differentiation measures in s ubdivided populations are proposed that can be applied to haplotypes p es (ordered alleles such as DNA sequences, which may contain a record of their own histories). Hence, two measures of differentiation can be compared for a single data set: one (G(ST)) that makes use only of th e allelic frequencies and the other (N-ST) for which similarities betw een the haplotypes are taken into account in addition. Tests are propo sed to compare N-ST and G(ST) with zero and with each other. The diffe rence between N-ST and G(ST) can be caused by several factors, includi ng sampling artefacts, unequal effect of mutation rates and phylogeogr aphic structure. The method presented is applied to a published data s et where a nuclear DNA sequence had been determined from individuals o f a grasshopper distributed in 24 regions of Europe. Additional insigh ts into the genetic subdivision of these populations are obtained by p rogressively combining related haplotypes and reanalyzing the data eac h time.