THE GLUCOSE-INDUCED SWITCH BETWEEN GLYCOGEN-PHOSPHORYLASE AND GLYCOGEN-SYNTHASE IN THE LIVER - OUTLINES OF A THEORETICAL APPROACH

The glucose-induced switch between glycogen phosphorylase and glycogen synthase in the liver is investigated by means of a theoretical appro ach based on a minimal, bicyclic cascade model involving the reversibl e phosphorylation of the two enzymes. The aim of the analysis is to ev aluate the contribution of different factors to the sequential changes in the activity of glycogen phosphorylase and glycogen synthase obser ved following the addition of suprathreshold amounts of glucose. (C) 1 996 Academic Press Limited.