Va. Lashkevich et al., SUPERACUTE LETHAL NECROSIS OF THE LIVER I N MONKEYS INFECTED WITH HIGH-PATHOGENIC VARIANTS OF ENTEROVIRUSES (ECHO-11 AND ECHO-19), Voprosy virusologii, 41(5), 1996, pp. 198-206
The authors studied the phenomenon of superhigh virulence for monkeys
of viruses ECHO 11 (E11) and ECHO 19 (E19) isolated in 1981-1991 in Ru
ssia and Tadzhikistan from children with acute enterovirus uveitis or
severe enterovirus infection. In 21 morphologically examined animals a
fter coma, macrofocal or total necrosis of hepatocytes in weak inflamm
ation was seen as early as experiment day 1-6. Hepatic lesion interpre
ted as hepatosis underlies acute hepatic failure with lethal outcome.
The most intensive reproduction of viruses E11 and E19 occurred in the
liver. Changes in the kidneys, lungs, spleen, adrenals, CNS detected
in many animals aggravated the disease, but were not the primary cause
of death. The disease in monkey was similar by the main criteria to s
uperacute lethal diseases (acute hepatic failure against massive hepat
ic necrosis, hemorrhagic syndrome) registered in outbreaks of E11 and
E19-virus infection in children in USA, Great Britain, Israel, Russia
and Ukraine. Monkeys can be used as man-adequate model for study of en
terovirus superacute lethal necrosis of the liver.