SUPERACUTE LETHAL NECROSIS OF THE LIVER I N MONKEYS INFECTED WITH HIGH-PATHOGENIC VARIANTS OF ENTEROVIRUSES (ECHO-11 AND ECHO-19)

Citation
Va. Lashkevich et al., SUPERACUTE LETHAL NECROSIS OF THE LIVER I N MONKEYS INFECTED WITH HIGH-PATHOGENIC VARIANTS OF ENTEROVIRUSES (ECHO-11 AND ECHO-19), Voprosy virusologii, 41(5), 1996, pp. 198-206
Citations number
40
Categorie Soggetti
Virology
Journal title
ISSN journal
05074088
Volume
41
Issue
5
Year of publication
1996
Pages
198 - 206
Database
ISI
SICI code
0507-4088(1996)41:5<198:SLNOTL>2.0.ZU;2-5
Abstract
The authors studied the phenomenon of superhigh virulence for monkeys of viruses ECHO 11 (E11) and ECHO 19 (E19) isolated in 1981-1991 in Ru ssia and Tadzhikistan from children with acute enterovirus uveitis or severe enterovirus infection. In 21 morphologically examined animals a fter coma, macrofocal or total necrosis of hepatocytes in weak inflamm ation was seen as early as experiment day 1-6. Hepatic lesion interpre ted as hepatosis underlies acute hepatic failure with lethal outcome. The most intensive reproduction of viruses E11 and E19 occurred in the liver. Changes in the kidneys, lungs, spleen, adrenals, CNS detected in many animals aggravated the disease, but were not the primary cause of death. The disease in monkey was similar by the main criteria to s uperacute lethal diseases (acute hepatic failure against massive hepat ic necrosis, hemorrhagic syndrome) registered in outbreaks of E11 and E19-virus infection in children in USA, Great Britain, Israel, Russia and Ukraine. Monkeys can be used as man-adequate model for study of en terovirus superacute lethal necrosis of the liver.