THE EFFICACY OF EVALUATION OF VIRUS-SPECI FIC PROTEINS IN IMMUNOGENESIS IN MARBURG VIRUS EXPERIMENTAL-INFECTION

Authors
DONCHENKO VV LEBEDEV VN MARKIN VA FIRSOVA IV
Citation
Vv. Donchenko et al., THE EFFICACY OF EVALUATION OF VIRUS-SPECI FIC PROTEINS IN IMMUNOGENESIS IN MARBURG VIRUS EXPERIMENTAL-INFECTION, Voprosy virusologii, 41(5), 1996, pp. 216-218
Citations number
10
Categorie Soggetti
Virology
Journal title
Voprosy virusologii → ACNP
ISSN journal
05074088
Volume
41
Issue
5
Year of publication
1996
Pages
216 - 218
Database
ISI
SICI code
0507-4088(1996)41:5<216:TEOEOV>2.0.ZU;2-H
Abstract
The protective properties of early virus-specific proteins (EVSP) of M arbug virus have been studied. Immunoglobulins to EVSP in combination with immunoglobulins to UV-inactivated Marbug virus prevented lethal i nfection in Marbug virus infected guinea pigs. More than 80% of guinea pigs immunized by mixture of EVSP and UV-inactivated Marbug virus sur vived after challenge with 25 LD(50) of Marbug virus. The explanation of this phenomenon and its further utilization are discussed.