NASAL SPRAY BROMOCRIPTINE - EFFECTS ON SERUM PROLACTIN IN PUERPERAL WOMEN

Background. The objective of this study was to investigate the effecti veness of a single nasal spray administration of 0.8 mg bromocriptine in reducing PRL serum levels. Methods. Eighteen physiologically hyperp rolactemic women in the early days of puerperium were randomized to re ceive nasal bromocriptine or placebo; PRL serum levels were measured b y RIA at 45, 30 and 15 minutes before the administration and after the following times: 15, 30, 45, 60, 120, 180, 240, 300, and 480 minutes. Results. After the administration of bromocriptine serum levels of PR L decreased rapidly; the reduction was statistically significant after 45 minutes. Four hours after the administration mean serum levels of PRL resulted in the normal range (<20 mu g/l); at the eighth hour the PRL levels were still normal. No one patient complained of any local o r systemic side-effects. Conclusion. Nasal route seems to be an effect ive and probably safe administration route for bromocriptine.