THE HUMAN INTESTINAL H+ OLIGOPEPTIDE COTRANSPORTER HPEPT1 TRANSPORTS DIFFERENTLY-CHARGED DIPEPTIDES WITH IDENTICAL ELECTROGENIC PROPERTIES/

Authors
MACKENZIE B FEI YJ GANAPATHY V LEIBACH FH
Citation
B. Mackenzie et al., THE HUMAN INTESTINAL H+ OLIGOPEPTIDE COTRANSPORTER HPEPT1 TRANSPORTS DIFFERENTLY-CHARGED DIPEPTIDES WITH IDENTICAL ELECTROGENIC PROPERTIES/, Biochimica et biophysica acta. Biomembranes, 1284(2), 1996, pp. 125-128
Citations number
9
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1284
Issue
2
Year of publication
1996
Pages
125 - 128
Database
ISI
SICI code
0005-2736(1996)1284:2<125:THIHOC>2.0.ZU;2-7
Abstract
The human intestinal H+/oligopeptide cotransporter hPEPT1, expressed i n Xenopus oocytes, transported neutral, anionic and cationic dipeptide s with identical electrogenic properties and maximal evoked currents. Currents were activated by 1 H+ regardless of the net charge on the dr iven substrate, and were independent of Na-o(+), K-i(+) and Cl-o(-), c alling into the question the familiar concept of the origin of the tra nsporter-mediated current.