Y. Takimoto et al., ANAPLASTIC LARGE-CELL LYMPHOMA (KI-1 LYMPHOMA) WITH EXPRESSION OF IL-5 MESSENGER-RNA AND EOSINOPHILIC INVASION, Acta haematologica, 96(4), 1996, pp. 245-248
We examined a patient with anaplastic large-cell lymphoma (Ki-1 lympho
ma) showing eosinophilic invasion of the tumor tissues, The number of
eosinophils in the peripheral blood changed as a function of the stage
of the disease. The IL-5 gene was expressed in the tumor tissues, sug
gesting that the eosinophilic invasion and eosinophilia were caused by
IL-5 derived from the lymphoma cells.