J. Wiltse et Vl. Dellarco, US ENVIRONMENTAL-PROTECTION-AGENCY GUIDELINES FOR CARCINOGEN RISK ASSESSMENT - PAST AND FUTURE, Mutation research. Reviews in genetic toxicology, 365(1-3), 1996, pp. 3-15
The U.S. Environmental Protection Agency (USEPA) recently proposed new
guidelines to update and replace the 1986 USEPA Guidelines for Carcin
ogen Risk Assessment, Today, there is a better understanding of the va
riety of modes by which carcinogens can operate that did not exist whe
n the 1986 USEPA guidelines were published, Many laboratories are addi
ng new test protocols in their programs directed at questions concerni
ng the mechanisms of action of carcinogens. In response to the evolvin
g science of carcinogenesis, the new guidelines provide an analytical
framework for incorporating all relevant biological information and re
cognizing a variety of situations regarding cancer risk, In addition,
the guidelines are flexible enough to allow consideration of future sc
ientific advances.