IS THERE A ROLE FOR HIGH-DOSE CHEMOTHERAPY WITH STEM-CELL RESCUE FOR BRAIN-STEM TUMORS OF CHILDHOOD

Authors
DUNKEL IJ OMALLEY B FINLAY JL
Citation
Ij. Dunkel et al., IS THERE A ROLE FOR HIGH-DOSE CHEMOTHERAPY WITH STEM-CELL RESCUE FOR BRAIN-STEM TUMORS OF CHILDHOOD, Pediatric neurosurgery, 24(5), 1996, pp. 263-266
Citations number
11
Categorie Soggetti
Pediatrics,"Clinical Neurology",Surgery
Journal title
Pediatric neurosurgery → ACNP
ISSN journal
10162291
Volume
24
Issue
5
Year of publication
1996
Pages
263 - 266
Database
ISI
SICI code
1016-2291(1996)24:5<263:ITARFH>2.0.ZU;2-O
Abstract
Diffuse pontine tumors are highly lethal and conventional therapy with irradiation provides long-term survival to a very small proportion of the patients. We have reported promising results using high-dose chem otherapy with autologous stem cell rescue in patients with recurrent h igh-grade astrocytomas in other anatomic locations, but our results an d those of others have been very discouraging in children with brain s tem tumors. Alternative strategies need to be developed for this highl y lethal disease.