PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF PATIENTS WITH INDIAN VISCERAL LEISHMANIASIS SUPPRESS NATURAL-KILLER-CELL ACTIVITY IN-VITRO

Authors
CHAKRABARTI G BASU A MANNA PP BHATTACHARYA S SEN S BANDYOPADHYAY S
Citation
G. Chakrabarti et al., PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF PATIENTS WITH INDIAN VISCERAL LEISHMANIASIS SUPPRESS NATURAL-KILLER-CELL ACTIVITY IN-VITRO, Transactions of the Royal Society of Tropical Medicine and Hygiene, 90(5), 1996, pp. 582-585
Citations number
20
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
90
Issue
5
Year of publication
1996
Pages
582 - 585
Database
ISI
SICI code
0035-9203(1996)90:5<582:PMOPWI>2.0.ZU;2-S
Abstract
Peripheral blood mononuclear cells (PBMC) of patients with Indian visc eral leishmaniasis (VL) suppressed the natural killer cell (NK) activi ty of normal human PBMC in vitro in a dose-dependent manner. Adherent monocytes, but not the non-adherent lymphocytes of VL patients suppres sed NK activity through soluble mediators. The level of suppression se en in different patients was variable.