BIOCONVERSION OF TA-HYDROXY-17-ALPHA-METHYL-ANDROSTA-1,4-DIEN-3-ONE AND ANDROSTA-1,4-DIENE-3,17-DIONE IN CULTURES OF THE GREEN-ALGA T76 SCENEDESMUS-QUADRICAUDA

Authors
DELLAGRECA M PREVITERA L FIORENTINO A PINTO G POLLIO A
Citation
M. Dellagreca et al., BIOCONVERSION OF TA-HYDROXY-17-ALPHA-METHYL-ANDROSTA-1,4-DIEN-3-ONE AND ANDROSTA-1,4-DIENE-3,17-DIONE IN CULTURES OF THE GREEN-ALGA T76 SCENEDESMUS-QUADRICAUDA, Tetrahedron, 52(44), 1996, pp. 13981-13990
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
44
Year of publication
1996
Pages
13981 - 13990
Database
ISI
SICI code
0040-4020(1996)52:44<13981:BOTA>2.0.ZU;2-B
Abstract
Exogenus 17 beta-hydroxy-17 alpha-methyl-androsta-1,4-dien- and andros ta-1,4-diene-3.17-dione are biotransformed by the green alga T76 Scene desmus quadricauda. The bioproducts have been isolated by chromatograp hic processes and identified on the basis of their spectroscopic featu res. Hydration of the Delta(4) double bond may justify the presence of the epimeric 5-hydroxyderivatives while rather complex skeleton rearr angements are involved in the formation of the remaining products. Cop yright (C) 1996 Published by Elsevier Science Ltd.