EFFECT OF NALOXONE ON THE LONG-TERM BODY-WEIGHT GAIN INDUCED BY REPEATED POSTNATAL STRESS IN MALE-MICE

Stress during the early postnatal life of laboratory animals can induc e body weight gain in adulthood. Exposure of mice to repeated postnata l stress has been shown to increase body weight some weeks after the r ecording of a hyposensitivity to thermal nociceptive stimulation. Sinc e the increase in nociceptive threshold after repeated environmental m anipulations can be interpreted as a behavioral index of stress-induce d endogenous opioid release, the present experiment was designed to st udy whether the stress-induced body weight gain could be prevented by a chronic treatment with the opioid antagonist naloxone. Sixteen litte rs of CD-1 male mice were used. Treatments took place from day 2 to da y 19 of postnatal life. As well as body weight we measured spontaneous motor activity and food and water consumption. Body length and epidid ymal fat pad weight were also measured, at the end of the experiment. Stress (i.e. a daily saline injection schedule) increased the rate of body weight gain and the epididymal fat pad weight; a daily injection schedule of naloxone did not induce these effects. No significant diff erences were evident among groups regarding body length, motor activit y, or food and water intake. The data suggest that repeated postnatal saline injections may induce long-term modifications in body and epidi dymal fat weights and that these effects may be mediated by endogenous opioids.