CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF SESQUITERPENE LACTONES ISOLATED FROM TANACETUM-PRAETERITUM SUBSP PRAETERITUM

Ten sesquiterpene lactones and one sesquiterpene isolated from Tanacet um praeteritum subsp. praeteritum: 1 alpha,6 alpha-dihydroxyisocostic acid methyl ester (2), 1 alpha-hydroxy-1-deoxoarglanine (3), douglanin (5), santamarin (6), reynosin (7), 1-epi-tatridin B (8), ludovicin A (10), armexin (12), armefolin (13), armexifolin (14), and 3 alpha-hydr oxyreynosin (15) were tested against the human lung carcinoma cell lin e GLC(4) and the colorectal cancer cell line COLO 320 as well as again st the bacteria Bacillus subtilis, Staphylococcus aureus, Proteus mira bilis, Escherichia coil, Klebsiella pneumoniae, Pseudomonas aeruginosa , Enterococcus, beta-hemolytic Streptococcus, and the yeast Candida al bicans. In addition, two germacranolides tatridin A (16) and tamirin ( 17) were included in the study. All compounds showed cytotoxic activit y (IC50 = 124 mu M) but most of them were not effective in the antimic robial tests.