HISTAMINERGIC AND SEROTONERGIC RECEPTOR BLOCKING SUBSTANCES FROM THE MEDICINAL PLANT GARCINIA-MANGOSTANA

Authors
CHAIRUNGSRILERD N FURUKAWA KI OHTA T NOZOE S OHIZUMI Y
Citation
N. Chairungsrilerd et al., HISTAMINERGIC AND SEROTONERGIC RECEPTOR BLOCKING SUBSTANCES FROM THE MEDICINAL PLANT GARCINIA-MANGOSTANA, Planta medica, 62(5), 1996, pp. 471-472
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
62
Issue
5
Year of publication
1996
Pages
471 - 472
Database
ISI
SICI code
0032-0943(1996)62:5<471:HASRBS>2.0.ZU;2-8
Abstract
A crude methanolic extract of the fruit hull of Mangosteen, Garcinia m ongostana L. inhibited the contractions of isolated thoracic rabbit ao rta induced by histamine and serotonin, The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pha rmacological activity to give alpha- and gamma-mangostin. On the basis of pharmacological data, it is suggested that alpha-mangostin and gam ma-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.