Ja. Garciarodriguez et al., IN-VITRO ACTIVITY OF MEROPENEM AGAINST CIPROFLOXACIN-RESISTANT ENTEROBACTERIACEAE AND PSEUDOMONAS-AERUGINOSA, Journal of chemotherapy, 8(5), 1996, pp. 358-364
The in-vitro susceptibilities of a total of 174 ciprofloxacin-resistan
t Enterobacteriaceae and Pseudomonas aeruginosa were determined. Accor
ding to the BSAC and NCCLS breakpoints, meropenem, aztreonam, ceftibut
en, ceftazidime, imipenem and cefotaxime were the most active (>90%) a
ntimicrobial agents tested against Enterobacteriaceae. Susceptibility
of these strains to piperacillin/tazobactam, cefpodoxime and cefixime
(84.96%) was higher than that to tobramycin, gentamicin and fosfomycin
(50-75%). More than 90% of P. aeruginosa were susceptible to meropene
m when both interpretative susceptibility breakpoint criteria were use
d. Piperacillin, piperacillin/tazobactam and ceftazidime were active a
gainst 50-75% of the same strains. Meropenem was the most active antim
icrobial tested against all ciprofloxacin-resistant clinical isolates
assayed.