RESULTS OF ADJUVANT CHEMOTHERAPY OF THE O PERATED HIGH-RISK CERVICAL-CARCINOMA

Patients with carcinoma of the cervix and histologically proven blood vessel invasion have a poor prognosis. At the I. Frauenklinik der Univ ersitat Munchen, 34 women were enrolled for a prospective study and we re alternatively treated with or without adjuvant chemotherapy (carbop latin and 5-fluorouracil). Of the 28 patients included in the follow-u p (14 with/14 without chemotherapy), 12 patients died (5 with/7 withou t chemotherapy). The disease-free interval was 18.6 months in the grou p treated with chemotherapy compared to 29.3 months in the group witho ut chemotherapy. There is no statistically significant difference in t he survival of patients with blood vessel invasion in relationship to adjuvant chemotherapy following radical hysterectomy.