Gc. Creatsas et al., ENDOTHELIN PLASMA-LEVELS IN PRIMARY AMENORRHEIC ADOLESCENTS BEFORE AND AFTER ESTROGEN-TREATMENT, Journal of the Society for Gynecologic Investigation, 3(6), 1996, pp. 350-353
OBJECTIVE: We evaluated the effect of estrogen administration on endot
helin (ET) secretion in primary amenorrheic (PA) adolescent girls. MET
HODS: Fifteen PA adolescents (ten hypergonadotropic, group A; five hyp
ogonadotropic, group B) were treated with estrogen and progestogen tab
lets. A control group of ten healthy adolescents (group C) was include
d in the study. The ET 1-21, FSH, and LH plasma levels were tested bef
ore treatment (PrT) and immediately after the last estrogen tablet but
before the progestogen administration (PoT). RESULTS: A statistically
significant difference (P < .01) in ET 1-21 plasma values was found b
etween PrT (9.66 +/- 0.80 pmol/L) and PoT (7.56 +/- 0.89 pmol/L) level
s in group A cases. A similar reduction (P < .05) was recorded between
PrT (8.06 +/- 0.46 pmol/L) and PoT (5.59 +/- 0.53 pmol/L) ET 1-21 pla
sma levels in group B cases. Endothelin 1-21 plasma PrT values were hi
gher in both group A and B cases in comparison with controls (6.66 +/-
0.44 pmol/L; P < .01, P < .1, respectively). CONCLUSIONS: Estrogens a
dministered to PA adolescents reduce ET 1-21 plasma levels in both hyp
er- and hypogonadotropism. Copyright (C) 1996 by the Society for Gynec
ologic Investigation.