THE EFFECT OF ASPALATONE, A NEW ANTITHROMBOTIC AGENT, ON THE SPECIFICACTIVITY OF ANTIOXIDANT ENZYME IN THE RAT-BLOOD

The antioxidant efficacy of aspalatone, a new antithrombotic agent, ha s been recognized in the neurotoxic model and in the cardiotoxic model in preliminary studies. We examined the specific activity of antioxid ant enzyme in the rat blood following administrations of aspirin, malt ol, aspirin together with maltol, salicylmaltol (major metabolite of a spalatone) and aspalatone, respectively. Our assessment showed that sa licylmaltol, maltol, aspalatone enhanced antiperoxidative activity. In addition, neither aspirin nor combination of aspirin and maltol, show ed any significant effect on the activity of antioxidant enzyme. Becau se H2O2 accumulation may stimulate the thrombogenesis in blood, the re sult suggests that the induction of blood antiperoxidative activity pr oduced by aspalatone may have beneficial effects on the thrombogenesis .