A NOVEL OCULAR DELIVERY SYSTEM FOR PHENYLEPHRINE HYDROCHLORIDE

The in vivo behaviour of phenylephrine hydrochloride in different vehi cles like gels of Carbopol 907(R), Carbopol 934P(R) and latex system o f cellulose acetate hydrogen phthalate (CAHP) was evaluated by measuri ng the reduction in intraocular pressure and the mydriatic activity. T he parameters that have been utilised to assess the performance of the formulations were the area under the curve (AUC), the maximum mydrias is (I-max), the time of maximum response (T-max) and the duration of a ctivity (D). The influence of viscosity and mucoadhesion on the bioava ilability parameters has also been investigated. Carbopol 934P and CAH P formulations showed prolonged duration of action and greater AUC com pared to Carbopol 907 and aqueous solution (P<0.05).