SYNTHESIS AND BIOLOGICAL-ACTIVITY OF C-3 PYRIDINYLETHENE-SUBSTITUTED CEPHALOSPORINS

Authors
KO SB LEE YS LEE JY HAM WH PARK HK
Citation
Sb. Ko et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF C-3 PYRIDINYLETHENE-SUBSTITUTED CEPHALOSPORINS, Archives of pharmacal research, 19(5), 1996, pp. 411-415
Citations number
7
Categorie Soggetti
Biology
Journal title
Archives of pharmacal research → ACNP
ISSN journal
02536269
Volume
19
Issue
5
Year of publication
1996
Pages
411 - 415
Database
ISI
SICI code
0253-6269(1996)19:5<411:SABOCP>2.0.ZU;2-N
Abstract
A series of aminothiazolylcephalosporin derivatives (1a similar to 1c) having pyridinylethenyl group at C-3 position was prepared starting f rom phosphonium salt 3 and 2-, 3- or 4-pyridinecarboxaldehyde and the antibacterial activity of these compounds was investigated. Among them , 4-pyridinylethenyl derivative was more active than 2- and 3-pyridiny lethenyl derivatives against Staphylococcus aureus and Escherichia col i.