PERSISTENCE OF CHROMOSOMAL-ABERRATIONS IN BLOOD-LYMPHOCYTES 11 YEARS AFTER CESSATION OF CMF THERAPY IN A BREAST-CANCER PATIENT

Authors
UDAYAKUMAR AM BHARGAVA MK
Citation
Am. Udayakumar et Mk. Bhargava, PERSISTENCE OF CHROMOSOMAL-ABERRATIONS IN BLOOD-LYMPHOCYTES 11 YEARS AFTER CESSATION OF CMF THERAPY IN A BREAST-CANCER PATIENT, Cancer letters, 107(1), 1996, pp. 1-3
Citations number
17
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
107
Issue
1
Year of publication
1996
Pages
1 - 3
Database
ISI
SICI code
0304-3835(1996)107:1<1:POCIB1>2.0.ZU;2-5
Abstract
Chromosomal aberrations were examined in a breast cancer patient 11 ye ars after cessation of cyclophosphamide methotraxate and 5-fluorouraci l (CMF) therapy. This indicates that they may well be derived from a p opulation of genetically damaged progenitor cells, from which abnormal and possibly malignant cell clones may have been generated, and a fra ction of these randomly occurring chromosome rearrangements appear to be 'stable'.