K. Date et al., SUPPRESSION OF T-LYMPHOCYTE PROLIFERATION BY PERITONEAL-MACROPHAGES IN CHICKENS, Developmental and comparative immunology, 20(3), 1996, pp. 183-191
The mechanism of the suppression of lymphocyte proliferation by perito
neal macrophages (MPs) in chickens and the presence of a suppressive s
ubstance in the culture supernatant of MPs were studied. The results s
howed that gelatin- and pepton-induced peritoneal MPs had an inhibitor
y accessory function against blastogenesis of mitogen-stimulated splen
ic lymphocytes and that resident peritoneal MPs had an enhanced access
ory function. The suppressive factor produced by gelatin-induced perit
oneal MPs is a protein having a pI of 3.6 and a molecular weight of 64
,000 and it is physically and chemically a relatively stable substance
. Moreover, it has no cytotoxic effect against lymphocytes and it was
verified that the suppressor in the culture supernatant of MPs was not
prostaglandin E(2) or alpha-acid glycoprotein. Copyright (C) 1996 Els
evier Science Ltd.