CYTOLOGY OF GRADE-1 PAPILLARY TRANSITIONAL-CELL CARCINOMA - A COMPARISON OF CYTOLOGIC, ARCHITECTURAL AND MORPHOMETRIC CRITERIA IN CYSTOSCOPICALLY OBTAINED URINE

OBJECTIVE: To assess the diagnostic criteria for grade 2 papillary tra nsitional cell carcinoma (TCC) in cystoscopically obtained urine. STUD Y DESIGN: We compared the sensitivity, specificity and positive predic tive value of cytologic, architectural and morphometric (primarily arc hitectural) criteria in 177 specimens with corresponding biopsy follow -up. RESULTS: Sensitivities ranged from 22% to 44%, specificities from 69% to 85% and positive predictive values from 59% to 66%, CONCLUSION : The currently described cytologic, architectural and morphometric cr iteria are inadequate for tile identification of grade 1 papillary TCC , and the cytologic diagnosis of grade 1 papillary TCC in cystoscopica lly obtained urine remains unreliable.