PRIMARY LUNG-CANCER ASSOCIATED WITH DIFFUSE GRANULOMATOUS LESIONS IN THE PULMONARY PARENCHYMA

A 60-year-old man was admitted to our hospital for productive cough. C hest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse microno dular shadows in both lung fields. A biopsied sample of the tumor reve aled squamous cell carcinoma, while noncaseating epithelioid cell gran ulomas were observed in the samples obtained by transbronchial lung bi opsy. The granulomas in the pulmonary parenchyma were determined to be sarcoid reactions secondary to lung cancer, since there was no eviden ce of sarcoidosis. Combination chemotherapy was effective for the tumo r, and the granulomas disappeared after completion of the chemotherapy . These findings suggest the presence of a relationship between sarcoi d reactions and lung cancer in this case.