Treatment of the 4-hydroxypyrazolo[1,5-a]pyridine with glycidyl tosyla
te in the presence of base, followed by reaction with isopropylamine g
ave 1-isopropylamino-3-(pyrazolo [1,5-a]pyrid-4-yloxy)-2-propanol. In
a similar manner, 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-6- and lami
no-3-(pyrazolo[1,5-a]pyrid-3-yloxy)-2-propanol were also prepared.