EFFICIENT KINETIC RESOLUTION OF 2-BENZENESULFONYLCYCLOPENTANONE DERIVATIVES (VOL 1, PG 115, 1996)

Authors
MAGUIRE AR KELLEHER LL FERGUSON G
Citation
Ar. Maguire et al., EFFICIENT KINETIC RESOLUTION OF 2-BENZENESULFONYLCYCLOPENTANONE DERIVATIVES (VOL 1, PG 115, 1996), Journal of molecular catalysis. B, Enzymatic, 2(2-3), 1996, pp. 147-158
Citations number
31
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular catalysis. B, Enzymatic → ACNP
ISSN journal
13811177
Volume
2
Issue
2-3
Year of publication
1996
Pages
147 - 158
Database
ISI
SICI code
1381-1177(1996)2:2-3<147:EKRO2D>2.0.ZU;2-H
Abstract
Efficient kinetic resolution of 2-benzenesulfonylcyclopentanones 1, be aring 3-alkyl, 3-aryl, or 3-benzyl substituents, has been achieved by bakers' yeast mediated reduction. With the unsubstituted 2-benzenesulf onylcyclopentanone la, efficient asymmetric reduction to form (1S,2R)- cis-2-benzenesulfonylcyclopentanol 2a is observed under the same condi tions. Excellent enantioselectivities (up to > 95% ee) are obtained.