PRIMATE ANALOG OF THE WISCONSIN CARD SORTING TEST - EFFECTS OF EXCITOTOXIC LESIONS OF THE PREFRONTAL CORTEX IN THE MARMOSET

Citation
R. Dias et al., PRIMATE ANALOG OF THE WISCONSIN CARD SORTING TEST - EFFECTS OF EXCITOTOXIC LESIONS OF THE PREFRONTAL CORTEX IN THE MARMOSET, Behavioral neuroscience, 110(5), 1996, pp. 872-886
Citations number
41
Categorie Soggetti
Neurosciences,"Behavioral Sciences
Journal title
ISSN journal
07357044
Volume
110
Issue
5
Year of publication
1996
Pages
872 - 886
Database
ISI
SICI code
0735-7044(1996)110:5<872:PAOTWC>2.0.ZU;2-0
Abstract
Using a primate analogue of the Wisconsin Card Sort Test, this study d emonstrated, for the first time, that lesions of the prefrontal cortex in monkeys produce a qualitatively similar impairment in attentional set-shifting to that seen following prefrontal cortical damage in huma ns. Although damage to the prefrontal cortex did not disrupt the abili ty of marmosets, a New World monkey, to maintain an attentional set, i t did disrupt their ability to shift an attentional set. It also impai red their performance on discrimination reversal, object retrieval, an d spatial delayed response, consistent with the effects of prefrontal damage in Old World monkeys. Comparison of the cognitive processes und erlying discrimination reversal, object retrieval, and attentional set -shifting reveals the various types of inhibitory control provided by the prefrontal cortex.