IDENTIFICATION OF RESIDUES IN ALPHA-MACROGLOBULINS INVOLVED IN ACTIVATION OF THE ALPHA(2)-MACROGLOBULIN SIGNALING RECEPTOR

Authors
HOWARD GC DECAMP DL MISRA UK PIZZO SV
Citation
Gc. Howard et al., IDENTIFICATION OF RESIDUES IN ALPHA-MACROGLOBULINS INVOLVED IN ACTIVATION OF THE ALPHA(2)-MACROGLOBULIN SIGNALING RECEPTOR, Biochimica et biophysica acta. Protein structure and molecular enzymology, 1297(2), 1996, pp. 111-114
Citations number
18
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Protein structure and molecular enzymology → ACNP
ISSN journal
01674838
Volume
1297
Issue
2
Year of publication
1996
Pages
111 - 114
Database
ISI
SICI code
0167-4838(1996)1297:2<111:IORIAI>2.0.ZU;2-W
Abstract
Site-directed mutagenesis of residues in the receptor binding fragment of rat alpha(1)-macroglobulin identify residues 1377 and 1378 (human numbering) as crucial for interaction with the alpha(2)M signaling rec eptor on murine macrophages. Secondary structure prediction and signal ing studies with the mutant proteins suggest the alpha(1)M signaling r eceptor binding site involves part of a loop-helix-loop motif comprise d of residues 1372-1378.